Work

Origin, Organization, Dynamics, and Function of Actin and Actomyosin Networks at the T Cell Immunological Synapse

Year: 2018

Type: review

Abstract: The engagement of a T cell with an antigen-presenting cell (APC) or activating surface results in the formation within the T cell of several distinct actin and actomyosin networks. These networks reside largely within a narrow zone immediately under the T cell's plasma membrane at its site of contact with the APC or activating surface, i.e., at the immunological synapse. Here we review the origin, organization, dynamics, and function of these synapse-associated actin and actomyosin networks. Importantly, recent insights into the nature of these actin-based cytoskeletal structures were made possible in several cases by advances in light microscopy.

Source: Annual Review of Immunology

DOI: 10.1146/annurev-immunol-042718-041341

Authors: John A. Hammer, Jia C. Wang, Mezida Saeed, Antonio T. Pedrosa

Institutions: National Institutes of Health, National Heart, Lung, and Blood Institute

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute

Award: Motor proteins and cytoskeletal dynamics in T cells, B cells and mesenchymal cells