Year: 2018
Type: article
Abstract: Glioma is one of the most common malignant tumors of the central nervous system and is characterized by extensive infiltrative growth, neovascularization, and resistance to various combined therapies. In addition to heterogenous populations of tumor cells, the glioma stem cells (GSCs) and other nontumor cells present in the glioma microenvironment serve as critical regulators of tumor progression and recurrence. In this review, we discuss the role of several resident or peripheral factors with distinct tumor-promoting features and their dynamic interactions in the development of glioma. Localized antitumor factors could be silenced or even converted to suppressive phenotypes, due to stemness-related cell reprogramming and immunosuppressive mediators in glioma-derived microenvironment. Furthermore, we summarize the latest knowledge on GSCs and key microenvironment components, and discuss the emerging immunotherapeutic strategies to cure this disease.
Source: Frontiers in Immunology
Authors: Qianquan Ma, Wenyong Long, Changsheng Xing, Junjun Chu, Mei Luo, Helen Y. Wang, Qing Liu, Rong-Fu Wang
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Awards: G1218041649, G1736252752, G3044447018, CPRIT Core for RNA Therapeutics and Research, G4807550264, G5354192954, Identification of novel immune targets and neoantigens for development of immunotherapy for breast cancer, G5989595523, Immunotherapy targeting triple negative breast cancer using NY-ESO-1-specific TCRs and blockade of immune suppression, G8927458838, G9000037935, G9000105761, G9000162200
OpenAlex ID: W2906664418