Work

Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo

Year: 2018

Type: article

Abstract: Significance Our discoveries provide evidence that posttranslational modification of Dicer1 drives aging, infertility, and metabolic disorder in mammals. These data suggest that phosphorylation of Dicer1 is a critical regulatory mechanism that dictates Dicer1 function and localization and provides a selective bias in miRNA processing. In addition, this work highlights the potential relevance of Dicer1 phosphorylation clinically, as Dicer1 mutations and expression levels do not account for all cases of Dicer1-associated disease.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1814377116