Work

Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers

Year: 2018

Type: review

Abstract: Obesity promotes the development of numerous cancers, such as liver and colorectal cancers, which is at least partly due to obesity-induced, chronic, low-grade inflammation. In particular, the recruitment and activation of immune cell subsets in the white adipose tissue systemically increase proinflammatory cytokines, such as tumor necrosis factor α (TNFα) and interleukin-6 (IL-6). These proinflammatory cytokines not only impair insulin action in metabolic tissues, but also favor cancer development. Here, we review the current state of knowledge on how obesity affects inflammatory TNFα and IL-6 signaling in hepatocellular carcinoma and colorectal cancers.

Source: Cancers

DOI: 10.3390/cancers11010024

Authors: Lara Kern, Melanie Mittenbühler, Anna Vesting, Anna Ostermann, Claudia Wunderlich, F. Wunderlich

Institutions: Max Planck Institute for Metabolism Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases

Language: English

Topic: Adipokines, Inflammation, and Metabolic Diseases

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499