Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure
Year: 2019
Type: article
Abstract: On March 1 and 2, 2018, the National Institutes of Health 2018 Progenitor Cell Translational Consortium, Cardiovascular Bioengineering Symposium, was held at the University of Alabama at Birmingham. Convergence of life sciences and engineering to advance the understanding and treatment of heart failure was the theme of the meeting. Over 150 attendees were present, and >40 scientists presented their latest work on engineering human functional myocardium for disease modeling, drug development, and heart failure research. The scientists, engineers, and physicians in the field of cardiovascular sciences met and discussed the most recent advances in their work and proposed future strategies for overcoming the major roadblocks of cardiovascular bioengineering and therapy. Particular emphasis was given for manipulation and using of stem/progenitor cells, biomaterials, and methods to provide molecular, chemical, and mechanical cues to cells to influence their identity and fate in vitro and in vivo. Collectively, these works are profoundly impacting and progressing toward deciphering the mechanisms and developing novel treatments for left ventricular dysfunction of failing hearts. Here, we present some important perspectives that emerged from this meeting.
Source: Circulation Research
Authors: Joel L. Berry, Wuqiang Zhu, Yao Liang Tang, Prasanna Krishnamurthy, Ying Ge, John P. Cooke, Yabing Chen, Daniel J. Garry, Huang-Tian Yang, Namakkal Soorapan Rajasekaran, Walter J. Koch, Song Li, Keitaro Domae, Gangjian Qin, Ke Cheng, Timothy J. Kamp, Lei Ye, Shijun Hu, Brenda M. Ogle, Jack M. Rogers, E. Dale Abel, Michael E. Davis, Sumanth D. Prabhu, Ronglih Liao, William T. Pu, Yibin Wang, Peipei Ping, Nenad Bursac, Gordana Vunjak-Novakovic, Joseph C. Wu, Roberto Bolli, Philippe Menasché, Jianyi Zhang
Institutions: University of Alabama at Birmingham, Augusta University, University of Wisconsin–Madison, Houston Methodist, University of Minnesota, Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, Temple University, University of California, Los Angeles, The University of Osaka, North Carolina State University, National Heart Centre Singapore, Soochow University, University of Iowa, Fraternal Order of Eagles, Georgia Institute of Technology, Emory University, The Wallace H. Coulter Department of Biomedical Engineering, UAB Medicine, Stanford Medicine, Stanford Cardiovascular Institute, Stanford University, Boston Children's Hospital, Duke University, Columbia University, University of Louisville, Hôpital Européen Georges-Pompidou
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1214307086, G1442900148, G2785986132, Cardiovascular Bioengineering (CVBE) Symposium - 2019, G2862769652, Endogenous and exogenous mechanisms that promote myocardial remuscularization in post infarction LV remodeling, G3426774557, Progenitor Cell Biology Consortium Administrative Coordinating Center, G3780378356, Engineering Vascularized Cardiac Muscle, G3891698115, G4600172635, G517282440, G5354210981, G6246914514, G6307788311, Understanding mitochondrial regulation of cardiac development and function through studies of Barth Syndrome, G6725649393, Enhancing vascular delivery of stem cells and microparticles, G703653045, G732570046, G7925271361, G8920713442
OpenAlex ID: W2907598783