Work

Combined hepatocellular cholangiocarcinoma (cHCC-CC): an update of genetics, molecular biology, and therapeutic interventions

Year: 2018

Type: article

Abstract: : Combined hepatocellular cholangiocarcinoma (CC) is a rare and aggressive primary hepatic malignancy with significant histological and biological heterogeneity. It presents with more aggressive behavior and worse survival outcomes than either hepatocellular carcinoma or CC and remains a diagnostic challenge. An accurate diagnosis is crucial for its optimal management. Major hepatectomy with hilar node resection remains the mainstay of treatment in operable cases. Advances in the genetic and molecular characterization of this tumor will contribute to the better understanding of its pathogenesis and shape its future management. Keywords: cholangiocarcinoma, hepatocellular carcinoma, combined, genetics, molecular biology, treatment, mixed liver tumors, primary liver cancer

Source: Journal of Hepatocellular Carcinoma

DOI: 10.2147/jhc.s159805

Authors: Chara Stavraka, Hannah Rush, Paul Ross

Institutions: Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, King's College Hospital NHS Foundation Trust, King's College Hospital

Language: English

Topic: Cholangiocarcinoma and Gallbladder Cancer Studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836