Year: 2019
Type: article
Abstract: BACKGROUND: Frailty and falls occur commonly and prematurely in HIV-infected populations. Whether frailty in middle-age predicts future falls among HIV-infected women is unknown. METHODS: We evaluated associations of frailty with single and recurrent falls 10 years later among 729 HIV-infected and 326 uninfected women in the Women's Interagency HIV Study (WIHS) with frailty measured in 2005 and self-reported falls in 2014-2016. Frailty was defined as ≥3 of 5 Fried Frailty Index components: slow gait, reduced grip strength, exhaustion, unintentional weight loss and low physical activity. Stepwise logistic regression models determined odds of single (versus 0) or recurrent falls (≥2 versus 0) during the 2-year period; separate models evaluated frailty components. RESULTS: HIV-infected women were older (median 42 versus 39 years; P<0.0001) and more often frail (14% versus 9%; P=0.04) than uninfected women. Over 2 years, 40% of HIV-infected versus 39% of uninfected women reported a fall (single fall in 15% HIV+ versus 18% HIV- women; recurrent falls in 25% HIV+ versus 20% HIV- women [overall P=0.20]). In multivariate models, frailty independently predicted recurrent falls (adjusted odds ratio [aOR] 1.84, 95% CI: 1.13, 2.97; P=0.01), but not a single fall. Among frailty components, unintentional weight loss independently predicted single fall (aOR 2.31, 95% CI: 1.28, 4.17; P=0.005); unintentional weight loss (aOR 2.26, 95% CI: 1.32, 3.86; P=0.003) and exhaustion (aOR 1.66, 95% CI: 1.10, 2.50; P=0.02) independently predicted recurrent falls. CONCLUSIONS: Early frailty measurement among middle-aged women with or at-risk for HIV may be a useful tool to assess future fall risk.
Source: Antiviral Therapy
DOI: 10.3851/imp3286
Institutions: Albert Einstein College of Medicine, Rutgers, The State University of New Jersey, New York Medical College, SUNY Downstate Health Sciences University, Georgetown University Medical Center, San Francisco VA Medical Center, University of California, San Francisco, Hektoen Institute, Cook County Health and Hospitals System, Columbia University Irving Medical Center, Columbia University
Language: English
Field: Health Professions
Domain: Health Sciences
Open Access status: green
Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: The Connie Wofsy Women's HIV Study, Brooklyn Women's Interagency HIV Study (WIHS) V, WIHS Data Management and Analysis Center (WDMAC), Chicago WIHS Consortium V (CWC), Washington Women's Interagency HIV/AIDS Study, Women's Interagency HIV Study (WIHS-V), Data Analysis and Coordination Center for the MACS-WIHS Combined Cohort Study
OpenAlex ID: W2907928233