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The Effect of Vitamin D on Cellular Pathways of Diabetic Nephropathy.

Year: 2019

Type: article

Abstract: BACKGROUND: Diabetic nephropathy is one of the most important microvascular complications and a major cause of morbidity and mortality in diabetic patients. This study was designed to investigate the effect of vitamin D on the expression of three key genes involved in the development of diabetic nephropathy. METHODS: ) gene expression were assessed in kidney tissue at the end of the experiment. RESULTS: , a key regulatory enzyme in the hexosamine pathway, was significantly reduced following vitamin D administration. CONCLUSION: Vitamin D may reduce diabetic nephropathy not only by improving blood glucose and insulin levels, but also by modulating hexosamine pathways in kidney.

Source: Europe PMC (PubMed Central)

Authors: Hoda Derakhshanian, Abolghassem Djazayery, Mohammad Hassan Javanbakht, Mohammad Reza Eshraghian, Abbas Mirshafiey, Mahnaz Zarei, Ehsan Alvandi, Ehsan Djalali, Mahmoud Djalali

Institutions: Alborz University of Medical Sciences, Tehran University of Medical Sciences, Islamic Azad University, Tehran, Islamic Azad University, Science and Research Branch

Language: English

Topic: Chronic Kidney Disease and Diabetes

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2908008155

FWCI: 1.734

Cites: 26

Cited by: 21

Related to: 10