Obesity-Induced Peritoneal Dissemination of Ovarian Cancer and Dominant Recruitment of Macrophages in Ascites
Year: 2018
Type: article
Abstract: One-fifth of cancer deaths are associated with obesity.Because the molecular mechanisms by which obesity affects the progression of ovarian cancer (OC) are poorly understood, we investigated if obesity could promote the progression of OC cells using the postmenopausal ob/ob mouse model and peritoneal dissemination of mouse ID8 OC cells.Compared to lean mice, obese mice had earlier OC occurrence, greater metastasis throughout the peritoneal cavity, a trend toward shorter survival, and higher circulating glucose and proinflammatory chemokine CXCL1 levels.Ascites in obese mice had higher levels of macrophages (Mφ) and chemokines including CCL2, CXCL12, CXCL13, G-CSF and M-CSF.Omental tumor tissues in obese mice had more adipocytes than lean mice.Our data suggest that obesity may accelerate the peritoneal dissemination of OC through higher production of pro-inflammatory chemokines and Mφ recruitment.
Source: Immune Network
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Awards: Mechanism of manganese-induced impairment of astrocytic glutamate transporters, Roles of proinflammatory chemokines linking obesity and breast cancer, Roles of inflammation-driven chemokines in the pathogenesis of ovarian cancer, 1/3) MMC, VICC, and TSU: Partners in Eliminating Cancer Disparities, (3 of 3) MMC, VICC & TSU: Partners in Eliminating Cancer Disparities, Mechanisms associated with neuroprotection from Mn-induced neurotoxicity.
OpenAlex ID: W2908018265