Work

Transient Receptor Potential-Melastatin Channel Family Member 2: Friend or Foe.

Year: 2017

Type: article

Abstract: overload or enhanced inflammatory response. Recent studies show that Trpm2 protects lungs from endotoxin-induced injury by reducing reactive oxygen species production in phagocytes; and improves cardiac function after ischemia-reperfusion injury by preserving mitochondrial respiration and cellular adenosine triphosphate levels while decreasing reactive oxygen species levels. In neuroblastoma xenografts, Trpm2 overexpression promotes tumor growth through modulation of hypoxia-inducible transcription factor expression and cellular bioenergetics; whereas Trpm2 inhibition results in enhanced sensitivity to doxorubicin. The robust expression in cancer cells and its pro-survival and proliferative properties make Trpm2 a rational target for cancer therapy. Indiscriminate Trpm2 inhibition, however, may engender serious untoward side effects in other vital organs.

Source: Europe PMC (PubMed Central)

Authors: Joseph Y Cheung, Barbara A Miller

Language: English

Topic: Ion Channels and Receptors

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: TRPM2, Mitochondria, and Cell Survival, Phospholemman and Cardiac Contracility, Involvement of BAG3 in HIV-1 induced cardiomyopathy, Exercise training in post-infarct heart, Trpm2: A novel target in Onco-cardiology, Signal Transduction Mechanisms of Erythropoietin

OpenAlex ID: W2908589885

FWCI: 0.671

Cites: 89

Cited by: 22

Related to: 10