Clade C HIV-1 Envelope Vaccination Regimens Differ in Their Ability To Elicit Antibodies with Moderate Neutralization Breadth against Genetically Diverse Tier 2 HIV-1 Envelope Variants
Year: 2019
Type: article
Abstract: Despite much progress, we still do not have a clear understanding of how to elicit a protective neutralizing antibody response against HIV-1 through vaccination. There have been great strides in the development of envelope immunogens that mimic the virus particle, but less is known about how different vaccination modalities and adjuvants contribute to shaping the antibody response. We compared seven different vaccines that were administered to rhesus macaques and that delivered the same envelope protein through various modalities and with different adjuvants. The results demonstrate that some vaccine components are better than others at eliciting neutralizing antibodies with breadth.
Source: Journal of Virology
DOI: 10.1128/jvi.01846-18
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Awards: Determinants of Neutralization Breadth in Early HIV-1 Infection, G1630272651, Using DNA/MVA/protein immunization of rhesus macaques to investigate how the background of the HIV-1 envelope and nature of the protein boost shape the genetic and functional antibody landscape., G3478762533, G3915849646, B-cell Biology of Mucosal Immune Protection from SIV Challenge, B and T Cell Biology of Protection from and Eradication of SIV/SHIV Infection, G9000029372, G9000118633, G9000272321, G9000309459
OpenAlex ID: W2908738511