Work

Modelling CAR-T therapy in humanized mice

Year: 2019

Type: article

Abstract: In the current issue of EBioMedicine, Jin et al. demonstrated a humanized mouse (hu-mouse) model in which a functional human immune system was established and genetically-matched (autologous) to primary acute B-lymphoblastic leukemia (B-ALL) in severe immunodeficient NSG mice [1]. Using this hu-mouse model, the authors generated CD19-targeted chimeric antigen receptor (CAR) T cells from human autologous mature T cells and tested the efficacy of CAR-T therapy against primary B-ALL.

Source: EBioMedicine

DOI: 10.1016/j.ebiom.2019.01.029

Authors: Yongxia Wu, Xue-Zhong Yu

Institutions: Medical University of South Carolina, MUSC Hollings Cancer Center

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,500