Work

A Mouse Model of Postoperative Pain

Year: 2019

Type: article

Abstract: Postoperative pain is highly debilitating and hinders recovery. Opioids are the main pain medication used for acute postoperative pain. Given the devastating opioid addiction and overdose epidemic across the US, non-opioid pain therapeutics are desperately needed. In order to develop novel, non-opioid therapies for the treatment of postoperative pain and identify the mechanisms underlying this pain, rodent models of incisional pain have been established. The protocol herein describes in detail how to create a mouse model of postoperative pain that was adapted from established protocols. This model of postoperative pain is frequently-used, highly reproducible, and results in peripheral and central nervous system alterations.

Source: BIO-PROTOCOL

DOI: 10.21769/bioprotoc.3140

Authors: Ashley Cowie, Cheryl Stucky

Institution: Medical College of Wisconsin

Language: English

Topic: Pain Mechanisms and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Medical College of Wisconsin, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke