Work

Circular RNA: a novel biomarker and therapeutic target for human cancers

Year: 2019

Type: review

Abstract: Circular (circ)RNAs, a newly recognized class of noncoding RNA, have been implicated in the occurrence and development of several diseases, including neurological and cardiovascular diseases. Studies of human tumors, including those of liver cancer, gastric cancer, lung cancer and colorectal cancer, have shown differential expression profiles of circRNAs, suggesting regulatory roles in cancer pathogenesis and metastasis. In this review, we discuss the most recent research into tumor-related circRNAs, providing a comprehensive summary of the expression or/and function of these circRNAs and proposing rational perspectives on the potential clinical application of circRNAs as helpful biomarkers or therapeutic targets in human tumors.

Source: International Journal of Medical Sciences

DOI: 10.7150/ijms.28047

Authors: Bo Lei, Zhiqiang Tian, Weiping Fan, Bing Ni

Institutions: Army Medical University, Shanxi Medical University, Southwest University, State Key Laboratory of Silkworm Genomic Biology

Language: English

Topic: Circular RNAs in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,337