Year: 2018
Type: article
Abstract: BackgroundsIn 1995, one technical article titled "The use of areas under curves in diabetes research" has been published [1].It criticized the abuse of incremental area under curve (iAUC).Now, we are interested to revisit this title using the update view.The area under the curve (AUC) is derived from the oral glucose tolerance test (OGTT) which is widely used to diagnose the impaired glucose tolerance (IGT) in the clinic.It is going to estimate the total rise in blood glucose during OGTT, calculating from the trapezium rule, trapezoidal method, or composite trapezoidal method as described previously [1].But, AUC is usually calculated using the trapezoidal rule now.The application of iAUC is developed due to the variations in fasting plasma glucose between individuals.But, the iAUC from subtracting the baseline value of fasting plasma glucose has been challenged as problematic [1] due to the formation of negative value(s).Therefore, the positive incremental AUC (pAUC) has further been suggested and only the values above the baseline value were considered to apply in the studies [2,3].On the other word, the total area under the curve (tAUC), incremental area under the curve (iAUC), and positive incremental area under the curve (pAUC) were applied in clinical practice.However, the cut-off baseline values (iAUC) are still concerned, either in the mathematical view [1] or from the clinical report [4].Recently, it has been indicated that tAUC expressed the best correlation with the 2-hour glucose level of OGTT and the total glucose response was represented by the tAUC better than iAUC or pAUC in a clinical report [5].The advantage of iAUC seems limited in the clinical practice. Application of iAUC in clinical practiceThe iAUC value is also applied to calculate the Glycemic Index (GI) of food in nutrition [6].The invited volunteer(s) were the healthyThe Areas Under Curves (AUC) used in diabetes research: Update view
Source: Integrative Obesity and Diabetes
DOI: 10.15761/iod.1000212
Institutions: Kagoshima University, Chi Mei Medical Center
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2909340514