Work

Effects of KPC Variant and Porin Genotype on the In Vitro Activity of Meropenem-Vaborbactam against Carbapenem-Resistant Enterobacteriaceae

Year: 2019

Type: article

Abstract: Meropenem-vaborbactam is a new agent with the potential to treat carbapenem-resistant Enterobacteriaceae (CRE) infections. We describe the in vitro activity of meropenem-vaborbactam against representative CRE genotypes and laboratory-engineered Escherichia coli isolates harboring mutant bla KPC genes associated with ceftazidime-avibactam resistance.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02048-18

Authors: William R. Wilson, Ellen G. Kline, Chelsea E. Jones, Kristin T. Morder, Roberta T. Mettus, Yohei Doi, M. Hong Nguyen, Cornelius J. Clancy, Ryan K. Shields

Institutions: University of Pittsburgh, University of Pittsburgh Medical Center, VA Pittsburgh Healthcare System

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institute of Allergy and Infectious Diseases, NIH Clinical Center

Awards: Caspofungin pharmacokinetics-pharmacodynamics during intra-adbominal candidiasis, Evolution of KPC-K pneumoniae that persist in patients on prolonged antibiotics, Study Network of Acinetobacter as a Carbapenem-Resistant Pathogen (SNAP), Colistin resistance in extensively drug-resistant Gram-negative pathogens, Characterization and suppression of resistance to new CRE agents, Chromosomal and plasmid contributions to colistin resistance and virulence in KPC-producing Klebsiella pneumoniae, Mechanisms and implications of fosfomycin resistance in Escherichia coli

OpenAlex ID: W2909686608

FWCI: 3.89

Cites: 32

Cited by: 85

Related to: 10