Tumour necrosis factor‐α‐induced protein 8‐like 2 is a novel regulator of proliferation, migration, and invasion in human rectal adenocarcinoma cells

Year: 2019

Type: article

Abstract: Tumour necrosis factor-α-induced protein 8-like 2 (TIPE2) is a tumour suppressor in many types of cancer. However, the mechanism of action of TIPE2 on the growth of rectal adenocarcinoma is unknown. Our results showed that the expression levels of TIPE2 in human rectal adenocarcinoma tissues were higher than those in adjacent non-tumour tissues. Overexpression of TIPE2 reduced the proliferation, migration, and invasion of human rectal adenocarcinoma cells and down-regulation of TIPE2 showed reverse effects. TIPE2 overexpression increased apoptosis through down-regulating the expression levels of Wnt3a, phospho (p)-β-Catenin, and p-glycogen synthase kinase-3β in rectal adenocarcinoma cells, however, TIPE2 knockdown exhibited reverse trends. TIPE2 overexpression decreased autophagy by reducing the expression levels of p-Smad2, p-Smad3, and transforming growth factor-beta (TGF-β) in rectal adenocarcinoma cells, however, TIPE2 knockdown showed opposite effects. Furthermore, TIPE2 overexpression reduced the growth of xenografted human rectal adenocarcinoma, whereas TIPE2 knockdown promoted the growth of rectal adenocarcinoma tumours by modulating angiogenesis. In conclusion, TIPE2 could regulate the proliferation, migration, and invasion of human rectal adenocarcinoma cells through Wnt/β-Catenin and TGF-β/Smad2/3 signalling pathways. TIPE2 is a potential therapeutic target for the treatment of rectal adenocarcinoma.

Source: Journal of Cellular and Molecular Medicine

DOI: 10.1111/jcmm.14065

Authors: Dong‐Dong Wu, Shi‐Yu Liu, Ying‐Ran Gao, Dan Lu, Ya Hong, Ya‐Ge Chen, Peng‐Zhen Dong, Da‐Yong Wang, Tao Li, Hui‐Min Li, Zhi‐Guang Ren, Jian‐Cheng Guo, Fei He, Xue‐Qun Ren, Shi‐Yong Sun, Shao‐Feng Duan, Xin‐Ying Ji

Institutions: Henan University, First Affiliated Hospital of Henan University, Zhengzhou University, Henan University Huaihe Hospital and Huaihe Clinical Institute, Emory University, Winship Cancer Institute

Language: English

Topic: Mechanisms of cancer metastasis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800

Funders: National Natural Science Foundation of China, Henan University, Education Department of Henan Province, Science and Technology Department of Henan Province

OpenAlex ID: W2909704159