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A confirmation of chronic graft-versus-host disease prediction using allogeneic HY antibodies following sex-mismatched hematopoietic cell transplantation

Year: 2019

Type: article

Abstract: A confirmation of chronic graft-versus-host disease prediction using allogeneic HY antibodies following sex-mismatched hematopoietic cell transplantation Chronic graft-versus-host disease (cGvHD) limits the effectiveness of hematopoietic cell transplantation (HCT) and often leads to significant morbidity and non-relapse mortality. 1We have previously shown that antibodies targeting Y-chromosome encoded proteins (HY antibodies) detected at 3-months post transplant in male HCT patients who receive grafts from a female donor (F→M) are associated with cGvHD development, non-relapse mortality (NRM), and decreased overall survival (OS). 2,3However, it is not known if this marker can be applied to the general population.In this multi-center, retrospective cohort study, we measured HY antibody levels in 234 F→M HCT patients with either plasma or serum samples collected at both the 3-month and 1-year post-transplant time points and determined the multivariable-adjusted relationship between the presence of multiple HY antibodies (represented as HY score) and cGvHD development.We quantified antibodies against the five most inform-

Source: Haematologica

DOI: 10.3324/haematol.2018.199646