Work

Phosphine-promoted [4 + 3] annulation of allenoate with aziridines for synthesis of tetrahydroazepines: phosphine-dependent [3 + 3] and [4 + 3] pathways

Year: 2019

Type: article

Abstract: In this manuscript, phosphine-dependent [3 + 3] and [4 + 3] annulation reactions of allenoate with aziridines were disclosed. The alkyldiphenylphosphine-promoted [4 + 3] annulation of allenoate with aziridines has been achieved under mild conditions, providing biologically interesting functionalized tetrahydroazepines in moderate to excellent yield with moderate to excellent regioselectivity and diastereoselectivity.

Source: RSC Advances

DOI: 10.1039/c8ra09852b

Authors: Honglei Liu, Yan Lin, Yan Zhao, Miaoren Xiao, Leijie Zhou, Qijun Wang, Cheng Zhang, Dongqi Wang, Ohyun Kwon, Hongchao Guo

Institutions: China Agricultural University, Chinese Academy of Sciences, Institute of High Energy Physics, University of California, Los Angeles

Language: English

Topic: Phosphorus compounds and reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funders: National Natural Science Foundation of China, National Institutes of Health, Chinese Universities Scientific Fund, National Institute of General Medical Sciences

Awards: G2435447757, G5420577716, 多尺度模拟方法研究铀镎与运铁蛋白的相互作用, G7994618610, G8228112919, G8360424711, G840576615, G8575143489, G9000168620

OpenAlex ID: W2910840769

FWCI: 0.747

Cites: 97

Cited by: 12

Related to: 10