Work

Acute kidney injury: an unusual complication of posaconazole use

Year: 2018

Type: article

Abstract: Triazole antifungals are useful in the treatment of Aspergillus disease and these drugs have side effects which clinicians should be aware of. Posaconazole is an orally administered second-generation triazole antifungal agent which inhibits lanosterol 14-alpha-demethylase, an enzyme that converts lanosterol to ergosterol, a vital component of the fungal cell membrane. Posaconazole has a favorable side effect profile, is safe and well tolerated when compared to the earlier generation of triazole antifungals. Common side effects of posaconazole include gastrointestinal, hepatobiliary, neurological, and skin and subcutaneous disorders. Renal disorders are classed as an uncommon side effect of posaconazole, occurring in ∼0.1-1% of patients. We describe 2 episodes of acute kidney injury (AKI) in a Caucasian whose Aspergillus lung disease was being treated with posaconazole. Regular monitoring of renal function may be necessary for patients on posaconazole to facilitate early identification of acute kidney injury which is reversible.

Source: Journal of Chemotherapy

DOI: 10.1080/1120009x.2018.1522472

Authors: Akaninyene Otu, Felix Bongomin, Chris Kosmidis, David W. Denning

Institutions: University of Calabar, Manchester University NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2910877299

FWCI: 0.567

Cites: 13

Cited by: 5

Related to: 10