Work

Not All Insults Are Created Equal for Awakening Dormant Stem Cell Abilities

Year: 2019

Type: article

Abstract: The intestinal epithelium is a highly proliferative tissue comprising several differentiated cell types that originate from multipotent, self-renewing intestinal stem cells. In 1974, Cheng and Leblond1 described crypt-based columnar cells (CBCs), which are self-renewing stem cells that are now thought to fuel day-to-day replenishment of cells within the intestinal epithelium. CBCs, identified by Lgr5 expression, are highly proliferative but are sensitive to damaging insults. Potten2 first identified label-retaining cells at the +4 crypt position as reserve stem cells that can be mobilized in response to damage to CBCs.

Source: Cellular and Molecular Gastroenterology and Hepatology

DOI: 10.1016/j.jcmgh.2018.12.003

Authors: Paige N. Vega, Ken S. Lau, James R. Goldenring

Institutions: Vanderbilt University, Nashville VA Medical Center, Vanderbilt University Medical Center

Language: English

Topic: Digestive system and related health

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000