Role of mitochondrial STAT3 in the metabolism of mouse embryonic stem cells
Year: 2018
Type: dissertation
Abstract: Stat3 is a transcription factor activated by the cytokine LIF (leukemia inhibitory factor) in mouse embryonic stem (ES) cells. The LIF/Stat3 axis maintains ES cell self-renewal through the induction of nuclear target genes such as Klf4 and Tfcp2l1. Here I report that Stat3 has a parallel function as a regulator of mitochondrial activity. Stat3 binds the mitochondrial DNA and increases the transcription of subunits of the respiratory chain, leading to increased respiration and optimal ES cell proliferation. Indeed, deletion of Stat3 results in reduced respiration and proliferation of ES cells.
Author: Riccardo Massimiliano Betto
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2910998364