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Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC

Year: 2019
Type: article
Abstract: Next-generation sequencing has provided information on actionable targets and biomarkers of response in oncology. In hepatocellular carcinoma (HCC), Wnt/CTNNB1 mutations characterize the immune-excluded class (cold tumors) and might represent the biomarkers predicting resistance to immune checkpoint inhibitors. Large-scale validation of these data is needed to customize immunotherapy in advanced HCC. See related article by Harding et al., p. 2116
DOI: 10.1158/1078-0432.ccr-18-3778
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: green
Funders: U.S. Department of Defense, Cancer Research UK, Generalitat de Catalunya, National Institutes of Health, Horizon 2020 Framework Programme, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, H2020 European Institute of Innovation and Technology
Awards: G1079996559, G3497250780, Integrative genomic analysis in hepatocellular carcinoma, G4119076191, G4139524798, G4280260777, G504963838, G5164162525, The Tisch Cancer Institute - Cancer Center Support Grant
OpenAlex ID: W2911120667
FWCI: 13.14
Cites: 10
Cited by: 255
Related to: 10