Work

Repurposing clinical trial data for skin cancer aetiology.

Year: 2018

Type: article

Abstract: In this issue of the BJD, Passarelli and colleagues provide randomized, placebo-controlled, clinical trial data on the effects of aspirin and folic acid and the risk of basal cell carcinoma (BCC). 1 The main findings were a modest nonsignificant increased risk of BCC associated with any aspirin use and no association with folic acid.However, subgroup analyses suggested that aspirin use may lead to a reduced risk of BCC among individuals with a history of skin cancer and an increased risk of BCC among those with no history of skin cancer, although these associations were also not significant.Despite relying on a small sample size and reporting largely null associations, the analysis adds high-quality data on the relationship between aspirin use, folic acid supplementation and subsequent risk of BCC.

Source: PubMed

DOI: 10.1111/bjd.16818

Author: E K Cahoon

Institutions: National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics

Language: English

Topic: Nonmelanoma Skin Cancer Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute