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Prime-Boost Immunizations with DNA, Modified Vaccinia Virus Ankara, and Protein-Based Vaccines Elicit Robust HIV-1 Tier 2 Neutralizing Antibodies against the CAP256 Superinfecting Virus

Year: 2019
Type: article
Abstract: A vaccine is urgently needed to combat HIV-1, particularly in sub-Saharan Africa, which remains disproportionately affected by the AIDS pandemic and accounts for the majority of new infections and AIDS-related deaths. In this study, two different vaccination regimens were compared. Rabbits that received two DNA primes followed by two modified vaccinia virus Ankara (MVA) and two protein inoculations developed better immune responses than those that received two MVA and three protein inoculations. In addition, DNA and MVA vaccines that expressed mosaic Gag VLPs presenting a stabilized Env antigen elicited better responses than Env alone, which supports the inclusion of Gag VLPs in an HIV-1 vaccine.
DOI: 10.1128/jvi.02155-18
Authors: Michiel T. van Diepen, Rosamund Chapman, Nicola Douglass, Shireen Galant, Penny L. Moore, Emmanuel Margolin, Phindile Ximba, Lynn Morris, Edward P. Rybicki, Anna-Lise Williamson
Institutions: University of Cape Town, Institute of Infectious Disease and Molecular Medicine, National Health Laboratory Service, University of the Witwatersrand, Centre for the AIDS Programme of Research in South Africa, National Institute for Communicable Diseases, University of KwaZulu-Natal
Language: English
Subfield: Virology
Open Access status: hybrid
OpenAlex ID: W2911339379
FWCI: 3.175
Cites: 109
Cited by: 36
Related to: 10