Work

Visible light-induced direct α C–H functionalization of alcohols

Year: 2019

Type: article

Abstract: Considering the synthetic value of introducing active alcoholic hydroxyl group, developing C–H functionalization of alcohols is of significance. Herein, we present a photochemical method that under visible light irradiation, selectfluor can effectively promote the oxidative cross-coupling between alcohols and heteroarenes without the external photocatalysis, achieving the selective α sp3 C–H arylation of alcohol, even in the presence of ether. The N-F activation of selectfluor under blue LEDs irradiation is evidenced by electron paramagnetic resonance (EPR) study, which is the key process for the oxidative activation of α sp3 C–H alcohols. The observed reactivity may have significant implications for chemical transformations.

Source: Nature Communications

DOI: 10.1038/s41467-019-08413-9

Authors: Linbin Niu, Jiamei Liu, Xing-An Liang, Shengchun Wang, Aiwen Lei

Institution: Wuhan University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $5,200

Funders: National Natural Science Foundation of China, Project 211