Searching for the needle in the haystack: deconvoluting the evolutionary dynamics of residual disease in human glioblastoma
Year: 2019
Type: editorial
Abstract: The evolution of divergent subpopulations of cancer cells within the same tumour has been proposed to underlie the development of treatment resistance and the recurrence of malignancy across multiple tumour types [1]. In this issue of Annals of Oncology, Spiteri et al. [2] utilise multi-region whole-exome sequencing to unravel the complex nature of cancer evolution in time and space that underlies glioblastoma (GBM) recurrence and offer novel insights into the phylogenetic relationships between the initial bulk tumour mass, clinically occult residual disease following initial radical therapy, and relapsed GBM.
Source: Annals of Oncology
Authors: S.T.C. Shepherd, K. Litchfield, S. Turajlic
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,250
Funders: National Institute on Handicapped Research, Wellcome Trust, Francis Crick Institute, NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research, Royal Marsden Cancer Charity, Cancer Research UK, National Institute for Health and Care Research, Rosetrees Trust, Medical Research Council
OpenAlex ID: W2911512712