Hydrophilic 18 F-labeled trans -5-oxocene (oxoTCO) for efficient construction of PET agents with improved tumor-to-background ratios in neurotensin receptor (NTR) imaging
Year: 2019
Type: article
Abstract: An 18F-labeled trans-5-oxocene (oxoTCO) that is used to construct a PET probe for neurotensin receptor (NTR) imaging through tetrazine ligation is described here. PET probe construction proceeds with 70% RCY based on 18F-oxoTCO and is completed within seconds. The in vivo behaviour of the oxoTCO based PET probe was compared with those of analogous probes that were prepared from 18F-labeled s-TCO and d-TCO tracers. The hydrophilic 18F-oxoTCO probe showed a significantly higher tumor-to-background ratio while displaying comparable tumor uptake relative to the 18F-dTCO and 18F-sTCO derived probes.
Source: Chemical Communications
DOI: 10.1039/c8cc09747j
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: The Tetrazine Ligation for Efficient 18F Labeling and Pretargeted Imaging/Radiotherapy of Cancer, Discovery of Chemical Probes and Therapeutic Leads, Phase II, CRIF:MU Cryprobe Upgrade of a NMR Spectrometer, Small Animal PET/CT for Preclinical Imaging Research, High Performance Digital NMR Spectrometer, Molecular Design of Advanced Biomaterials, MRI: Acquisition of a High Resolution Mass Spectrometer for Small Molecule Analysis, Cancer Center Support Grant, Q-Exactive Orbitrap LC-MC/MS System
OpenAlex ID: W2911650995