Work

MiR-216b functions as a tumor suppressor by targeting HMGB1-mediated JAK2/STAT3 signaling way in colorectal cancer.

Year: 2017

Type: article

Abstract: <0.05). Furthermore, we demonstrated that miR-216b inhibited cell proliferation, migration, invasion and angiogenesis by targeting HMGB1 which was highly expressed in CRC. Additionally, we proved that miR-216b promoted the development and progression of CRC, at least partially through HMGB1-mediated JAK2/STAT3 pathway. Lastly, we showed that plasma miR-216b expression was reduced in CRC when compared to healthy controls and might be a potential diagnostic biomarker for CRC. The findings indicated that miR-216b might function as a suppressor in CRC and could serve as a promising diagnostic and prognostic biomarker for CRC.

Source: PubMed

Authors: Xiaoxiang Chen, Xiangxiang Liu, Bangshun He, Yuqin Pan, Huiling Sun, Tao Xu, Xiuxiu Hu, Shukui Wang

Institutions: Nanjing First Hospital, Southeast University, Nanjing Medical University

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2911727816

FWCI: 1.571

Cites: 50

Cited by: 33

Related to: 10