Work

The Role of NMDA Receptors in Alzheimer’s Disease

Year: 2019

Type: review

Abstract: In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression and spine elimination. Memantine, low-affinity NMDAR channel blocker, has been used in the treatment of moderate to severe AD. However, clear evidence is still deficient in demonstrating the underlying mechanisms and a relationship between NMDARs dysfunction and AD. This review focuses on not only changes in expression of different NMDAR subunits, but also some unconventional modes of NMDAR action.

Source: Frontiers in Neuroscience

DOI: 10.3389/fnins.2019.00043

Authors: Jinping Liu, Lirong Chang, Yizhi Song, Hui Li, Yan Wu

Institutions: Tsinghua University, Capital Medical University, Beijing Institute for Brain Disorders

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950