The Expression of SOCS and NF-ϰB p65 in Hypopharyngeal Carcinoma.
Year: 2018
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Hypopharyngeal carcinoma is one of the most common types of head and neck tumors. Suppressers of cytokine signalling (SOCS) family members are key regulators of cytokine homeostasis, they play important roles in the process of cell proliferation, differentiation, maturation and apoptosis, and participate in the occurrence and development of tumor. The abnormal activation of NF-ϰB is an important feature of the tumor. The aim of this study was to investigate the relationships among SOCS, NF-ϰB p65 and hypopharyngeal carcinoma development.C. METHODS: We included 72 hypopharyngeal cancer patients and 9 swallow cyst patients. The patients were recruited at The Second Hospital of Shandong University (Jinan, China) between 2014 and 2016. The mRNA and protein expression levels of SOCS-1, SOCS-3 and NF-ϰB p65 in hypopharyngeal carcinoma tissues, para-cancerous tissues and control tissues were detected by RT-PCR and Western blot analysis, respectively. RESULTS: =0.04). CONCLUSION: SOCS-1, SOCS-3 may be protective factors while NF-ϰB p65 could be a harmful factor in hypopharyngeal carcinoma.
Source: Europe PMC (PubMed Central)
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2911802525