Utilization of a preclinical model for chemoprevention of esophageal cancer employing a food-based and single- agent approach
Year: 2004
Type: article
Abstract: Cancer incidence estimates for 2003 indicate that 18% of all cancers diagnosed originate in the aerodigestive tract, including the larynx, lung and bronchus, oral cavity, pharynx and esophagus.Specifically esophageal squamous cell carcinoma represents over 90% of all esophageal cancer cases.It is the 8 th leading cause of cancer and the 5 th leading cause of cancer death.Our laboratory has evaluated the chemopreventive potential of certain foods and a variety of single agents, including food-derived and synthetic compounds, in animal models of lung, colon and esophageal cancer.The goal of these studies was to determine the efficacy of food based and single agents for future use in human chemoprevention trials in individuals at high risk for esophageal cancer.Certain foods, particularly fruits and vegetables, contain a number of complex mixtures that possess preventative properties which may be active at multiple stages of carcinogenesis and / or have additive or synergistic effects.Following a food-based approach for cancer chemoprevention, we initially conducted a study to determine if a freeze-dried preparation of blueberries would inhibit Nnitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis.A singleagent strategy for cancer chemoprevention typically involves the use of an agent which targets a specific process in carcinogenesis.Earlier studies have Dedicated to my sisters,
Author: Robeena Aziz
Institution: The Ohio State University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W291196996