Adaptation of an R5 Simian-Human Immunodeficiency Virus Encoding an HIV Clade A Envelope with or without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants
Year: 2019
Type: article
Abstract: In this study, we constructed a simian-human immunodeficiency virus carrying an R5 Kenyan HIV-1 clade Aenv(SHIV-A). To bypass host immunity, SHIV-A was rapidly passaged in naive macaques or animals depleted of both CD8+and B cells. Next-generation sequencing identified different mutations that resulted from optimization of viral replicative fitness either in the absence of adaptive immunity or due to pressure from adaptive immune responses.
Source: Journal of Virology
DOI: 10.1128/jvi.02267-18
Authors: Mingkui Zhou, Michael Humbert, Muhammad M. Mukhtar, Hanna B. Scinto, Hemant K. Vyas, Samir K. Lakhashe, Siddappa N. Byrareddy, Gregor Maurer, Swati Thorat, Joshua Owuor, Zhao Lai, Yidong Chen, Anthony Griffiths, Agnès-Laurence Chenine, Sanjeev Gumber, François Villinger, David Montefiori, Ruth M. Ruprecht
Institutions: Texas Biomedical Research Institute, Harvard University, Dana-Farber Cancer Institute, The University of Texas at San Antonio Health Science Center, University of Veterinary Medicine Vienna, Henry M. Jackson Foundation, Emory University, Emory National Primate Research Center, Duke University, Duke Medical Center
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: G1114781936, Mays Cancer Center at UT Health SA, G1376570166, G2217690358, High Throughput DNA Sequencer: Illumina HiSeq 3000 Sequencer, G5129392908, Institute for Integration of Medicine & Science: A Partnership to Improve Health, Infant Immunoprophylaxis against a Primate Lentivirus, Defense-in-depth against mucosal HIV clade C invasion, Functional cure and virus eradication by early HAART plus vaccination with live attenuated rubella virus vectors in macaque infants and neonates, G9000118633, The Southwest National Primate Research Center
OpenAlex ID: W2912295684