Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life

Year: 2019

Type: article

Abstract: We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). We used data from the Atherosclerosis Risk in Communities (ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Mean global cortical standardized uptake value ratio (SUVR) >1.2 was defined as elevated. Midlife cognition was significantly associated with late-life cognition, but not with late-life elevated SUVR; education was not associated with late-life SUVR, but was strongly associated with late-life cognition. Cognitive reserve may reduce dementia risk by mitigating the impact of Alzheimer's disease pathology on the clinical expression of dementia, rather than by altering its pathogenesis.

Source: Journal of Alzheimer s Disease

DOI: 10.3233/jad-180785

Authors: Andreea M. Rawlings, A. Richey Sharrett, Thomas H. Mosley, Dean F. Wong, David S. Knopman, Rebecca F. Gottesman

Institutions: Johns Hopkins University, Kaiser Permanente Center for Health Research, University of Mississippi Medical Center, Johns Hopkins Medicine, Mayo Clinic

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute

OpenAlex ID: W2912361180