Kinetic and Cross-Sectional Studies on the Genesis of Hypoargininemia in Severe Pediatric Plasmodium falciparum Malaria
Year: 2019
Type: article
Study design: Observational Study
Abstract: The low bioavailability of nitric oxide (NO) and its precursor, arginine, contributes to the microvascular pathophysiology of severe falciparum malaria. To better characterize the mechanisms underlying hypoargininemia in severe malaria, we measured the plasma concentrations of amino acids involved in de novo arginine synthesis in children with uncomplicated falciparum malaria (UM; n = 61), children with cerebral falciparum malaria (CM; n = 45), and healthy children (HC; n = 109).
Source: Infection and Immunity
DOI: 10.1128/iai.00655-18
Institutions: Duke University, Duke Medical Center, Hubert Kairuki Memorial University, Charles Darwin University, Menzies School of Health Research, Nanyang Technological University, University of Utah, Intermountain Medical Center, Durham VA Medical Center, VA Salt Lake City Healthcare System, Lake City VA Medical Center
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Viral Zoonoses and Severe Febrile Illness in Northern Tanzania, Nitric Oxide and Microvascular Dysfunction in Severe Malaria, University of California Global Health Institute Program for Fellows and Scholars, Hyperphenylalaninemia in cerebral malaria, Arginine, Nitric Oxide, and Severe Malaria, Nitric Oxide and Severe Malaria, Nitric Oxide and Malaria
OpenAlex ID: W2912455416