Year: 2019
Type: article
Abstract: Background Myocardial T1 mapping shows promise for assessment of cardiomyopathies. Most myocardial T1 mapping techniques, such as modified Look–Locker inversion recovery (MOLLI), generate one T1 map per breath‐held acquisition (9–17 heartbeats), which prolongs multislice protocols and may be unsuitable for patients with breath‐holding difficulties. Purpose To develop and characterize novel shortened inversion recovery based T1 mapping schemes of 2–5 heartbeats. Study Type Prospective. Population/Phantom Numerical simulations, agarose/NiCl2 phantom, 16 healthy volunteers, and 24 patients. Field Strength/Sequence 1.5T/MOLLI. Assessment All shortened T1 mapping schemes were characterized and compared with a conventional MOLLI scheme (5‐(3)‐3) in terms of accuracy, precision, spatial variability, and repeatability. Statistical Tests Kruskal–Wallis, Wilcoxon rank sum tests, analysis of variance, Student's t‐tests, Bland–Altman analysis, and Pearson correlation analysis. Results All shortened schemes provided limited T1 time variations (≤2% for T1 times ≤1200 msec) and limited penalty of precision (by a factor of ~1.4–1.5) when compared with MOLLI in numerical simulations. In phantom, differences between all schemes in terms of accuracy, spatial variability, and repeatability did not reach statistical significance (P > 0.71). In healthy volunteers, there were no statistically significant differences between all schemes in terms of native T1 times and repeatability for myocardium (P = 0.21 and P = 0.87, respectively) and blood (P = 0.79 and P = 0.41, respectively). All shortened schemes led to a limited increase of spatial variability for native myocardial T1 mapping with respect to MOLLI (by a factor of 1.2) (P < 0.0001). In both healthy volunteers and patients, the two‐heartbeat scheme and MOLLI led to highly linearly correlated T1 times (correlation coefficients ≥0.83). Data Conclusion The proposed two‐heartbeat T1 mapping scheme yields a 5‐fold acceleration compared with MOLLI, with highly linearly correlated T1 times, no significant difference of repeatability, and limited spatial variability penalty at 1.5T. This approach may enable myocardial T1 mapping in patients with severe breath‐holding difficulties and reduce the examination time of multislice protocols. Level of Evidence: 1 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019;50:641–654.
DOI: 10.1002/jmri.26649
Institution: King's College London
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,698
Awards: Magnetic resonance Guided Ablation System for Treatment of ventricular Tachycardia (MR-GAST-VT), G1054121244, G1211483440, G1247657515, King's College London Medical Engineering Centre of Research Excellence, Novel Cardiac MRI techniques for the diagnosis of coronary artery disease compared to PET imaging and Invasive Coronary Angiography., G2311583330, G2417159676, G3171527865, G5296857752, King's College London Medical Engineering Centre of Research Excellence, Advanced Real-time MR-Guided Radiofrequency Ablation of Cardiac Arrhythmias, G8303168876, G8775246936, G938335843, G961285871
OpenAlex ID: W2912620904