Vitamin B6 catabolism and lung cancer risk: results from the Lung Cancer Cohort Consortium (LC3)
Year: 2019
Type: article
Abstract: BACKGROUND: Increased vitamin B6 catabolism related to inflammation, as measured by the PAr index (the ratio of 4-pyridoxic acid over the sum of pyridoxal and pyridoxal-5'-phosphate), has been positively associated with lung cancer risk in two prospective European studies. However, the extent to which this association translates to more diverse populations is not known. MATERIALS AND METHODS: For this study, we included 5323 incident lung cancer cases and 5323 controls individually matched by age, sex, and smoking status within each of 20 prospective cohorts from the Lung Cancer Cohort Consortium. Cohort-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between PAr and lung cancer risk were calculated using conditional logistic regression and pooled using random-effects models. RESULTS: PAr was positively associated with lung cancer risk in a dose-response fashion. Comparing the fourth versus first quartiles of PAr resulted in an OR of 1.38 (95% CI: 1.19-1.59) for overall lung cancer risk. The association between PAr and lung cancer risk was most prominent in former smokers (OR: 1.69, 95% CI: 1.36-2.10), men (OR: 1.60, 95% CI: 1.28-2.00), and for cancers diagnosed within 3 years of blood draw (OR: 1.73, 95% CI: 1.34-2.23). CONCLUSION: Based on pre-diagnostic data from 20 cohorts across 4 continents, this study confirms that increased vitamin B6 catabolism related to inflammation and immune activation is associated with a higher risk of developing lung cancer. Moreover, PAr may be a pre-diagnostic marker of lung cancer rather than a causal factor.
Source: Annals of Oncology
Authors: H. Zuo, P.M. Ueland, Ø Midttun, G.S. Tell, A. Fanidi, W. Zheng, X. Shu, Y. Xiang, J. Wu, R. Prentice, M. Pettinger, C.A. Thomson, G.G. Giles, A. Hodge, Q. Cai, W.J. Blot, M. Johansson, J. Hultdin, K. Grankvist, V.L. Stevens, M.L. McCullough, S.J. Weinstein, D. Albanes, R.G. Ziegler, N.D. Freedman, N.E. Caporaso, A. Langhammer, K. Hveem, M. Næss, J.E. Buring, I. Lee, J.M. Gaziano, G. Severi, X. Zhang, M.J. Stampfer, J. Han, A. Zeleniuch-Jacquotte, L.L. Marchand, J. Yuan, R. Wang, W. Koh, Y. Gao, U. Ericson, K. Visvanathan, M.R. Jones, C. Relton, P. Brennan, M. Johansson, A. Ulvik
Institutions: University of Bergen, Haukeland University Hospital, Bevital (Norway), University of Cambridge, MRC Epidemiology Unit, Centre international de recherche sur le cancer, Vanderbilt University, Vanderbilt-Ingram Cancer Center, Shanghai Jiao Tong University, Renji Hospital, Shanghai Cancer Institute, State Key Laboratory of Oncogene and Related Genes, Fred Hutch Cancer Center, University of Arizona, The University of Melbourne, Cancer Council Victoria, Umeå University, American Cancer Society, National Institutes of Health, Division of Cancer Epidemiology and Genetics, Norwegian University of Science and Technology, Brigham and Women's Hospital, Harvard University, VA Boston Healthcare System, Inserm, Université Paris-Saclay, Centre de recherche en Epidémiologie et Santé des Populations, Italian institute for Genomic Medicine, Indiana University Health, Indiana University Indianapolis, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, New York University, University of Hawaii Cancer Center, University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, National University of Singapore, Duke-NUS Medical School, Lund University, Johns Hopkins University, University of Bristol, MRC Integrative Epidemiology Unit, Newcastle University
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,250
Awards: Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer, G1416987869, Biochemical Markers in the nurses' Health Study Cohort, G2906079785, One-carbon metabolism biomarkers and lung cancer risk, G361298724, The NYU Women's Health Study, Dietary and Hormonal Determinants of Cancer in Women, G459566519, G5192599444, Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study, Cancer Epidemiology Cohort in Male Health Professionals, Novel molecular markers of lung cancer risk and survival, G9000019617, G9000122174
OpenAlex ID: W2912912813