Work

Software for Dosage Individualization of Voriconazole: a Prospective Clinical Study

Year: 2019

Type: article

Abstract: genotype-derived metabolizer phenotype with voriconazole AUC. Software can be used to adjust the dosages of voriconazole to achieve drug exposures that are safe and effective. (The clinical trial discussed in this paper has been registered in the European Clinical Trials Database under EudraCT no. 2013-0025878-34 and in the ISRCTN registry under no. ISRCTN83902726.).

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02353-18

Authors: William Hope, Gary Johnstone, Silvia Cicconi, Timothy Felton, Joanne Goodwin, Sarah Whalley, Anahi Santoyo-Castelazo, Virginia Ramos-Martin, Jodi Lestner, Leah Credidio, Aaron Dane, Daniel F. Carr, Munir Pirmohamed, Rahim Salim, Michael Neely

Institutions: University of Liverpool, Royal Liverpool and Broadgreen University Hospital NHS Trust, Broadgreen Hospital, Manchester Academic Health Science Centre, University of Manchester, Manchester University NHS Foundation Trust, Wythenshawe Hospital, University of Southern California

Language: English

Topic: Pharmacogenetics and Drug Metabolism

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institute for Health and Care Research, Pfizer UK, Medical Research Council, Research Trainees Coordinating Centre

Awards: Goal-oriented and model-based pharmokinetic dosing of voriconazole in immunocompromised patients, NIHR Senior Investigator Award, G570999748, G8401121362

OpenAlex ID: W2912916978

FWCI: 3.264

Cites: 12

Cited by: 22

Related to: 10