Infrequent Transmission of Monovalent Human Rotavirus Vaccine Virus to Household Contacts of Vaccinated Infants in Malawi
Year: 2019
Type: article
Study design: Observational Study
Abstract: Horizontal transmission of rotavirus vaccine virus may contribute to indirect effects of rotavirus vaccine, but data are lacking from low-income countries. Serial stool samples were obtained from Malawian infants who received 2 doses of monovalent human rotavirus vaccine (RV1) (days 4, 6, 8, and 10 after vaccination) and from their household contacts (8-10 days after vaccine). RV1 vaccine virus in stool was detected using semiquantitative real-time reverse-transcription polymerase chain reaction. RV1 fecal shedding was detected in 41 of 60 vaccinated infants (68%) and in 2 of 147 household contacts (1.4%). Horizontal transmission of vaccine virus within households is unlikely to make a major contribution to RV1 indirect effects in Malawi.
Institutions: University of Liverpool, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi, Yale University, Emory University, Centers for Disease Control and Prevention, Centre for Inflammation Research, University of Edinburgh, University College London, Johns Hopkins University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,763
Funders: GlaxoSmithKline, Sanofi, Wellcome Trust, National Institute for Health Research Health Protection Research Unit, National Institute for Health and Care Research, University of East Anglia, University of Oxford, University of Liverpool, Public Health England, National Institutes of Health, Centers for Disease Control and Prevention, Sanofi Pasteur, National Institute of Allergy and Infectious Diseases
Awards: G1623753052, Malawi-Liverpool-Welcome Trust Clinical Research Programme., Characterization of B-cell Subsets and Immunoglobulin Sequence Repertoires in Infants Immunised with Human Rotavirus Vaccine in Malawi, Wellcome Trust Clinical PhD Programme, University of Liverpool 'Health Priorities in the Developing World', New childhood vaccines for Malawi: Impact of a national pneumococcal and rotavirus vaccine roll-out on child mortality and disease burden, in a region of sub-optimal strain coverage., Malawi-Liverpool-Wellcome Trust Clinical Research Programme., Wellcome Trust Clinical PhD Programme, University of Liverpool 'Health Priorities in the Developing World', G7351858616, G7710325209, Modeling the impact and cost-effectiveness of next-generation rotavirus vaccine strategies in low- and middle-income countries, New childhood vaccines for Malawi: Impact of a national pneumococcal and rotavirus vaccine roll-out on child mortality and disease burden, in a region of sub-optimal strain coverage, G9000008919, G9000119472, G9000352597
OpenAlex ID: W2912974305