Year: 2019
Type: article
Abstract: Significance Microbial adaptation to the host environment is crucial for commensalism and pathogenesis. One adaptive strategy includes the production of lipolytic enzymes that allow acquisition of free fatty acids and disruption of lipid barriers. We demonstrate that a secreted lipase of Staphylococcus aureus also facilitates immune evasion by inactivating bacterial-derived lipoproteins, a pathogen-associated molecular pattern required for innate immune activation. Lipase activity changes the local inflammatory environment and promotes bacterial survival during infection. Thus, this work provides evidence that bacterial lipases can have unappreciated roles in immunomodulation. While many S. aureus -secreted virulence factors exert their effects directly on host cells, our study provides an interesting example of a bacterial enzyme that acts on endogenous substrates to mask immune recognition.
Authors: Xi Chen, Francis Alonzo
Institution: Loyola University Chicago
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2913035670