Work

A Wirelessly Controlled Fully Implantable Microsystem for Nano-liter Resolution Inner Ear Drug Delivery

Year: 2018

Type: conference-paper

Abstract: Site-directed and programmable drug delivery systems are important to leverage recent developments in protective and restorative biotherapies.Therapy development in the mouse model system requires advanced nano-liter precision implantable microsystems.Here, an implantable and scalable drug delivery system is presented consisting of a miniaturized, wirelessly controlled phase-change peristaltic micropump and a refillable microreservoir.3D-printing technology has been used to fabricate the micropump around a microcatheter tubing on the backside of a printed circuit board.In vitro characterization results demonstrate nano-liter resolution control over the desired flow rates of 10-100 nL/min in the presence of backpressure 40× larger than experienced in the physiologic system.In vivo implantation results show consistency with previously published syringe pump results.

Source: Solid-State Sensors, Actuators, and Microsystems Workshop (Hilton Head Workshop)

DOI: 10.31438/trf.hh2018.11