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Solventless and metal-free regioselective hydrofluorination of functionalized alkynes and allenes: an efficient protocol for the synthesis of gem -difluorides

Year: 2019

Type: article

Abstract: A highly acidic fluorination system generated by DMPU-12HF and KHSO 4 -13HF can facilitate exclusive Markovnikov addition of HF to widely functionalized alkynes and allenes to produce gem -difluorides with an easy workup.

Source: Green Chemistry

DOI: 10.1039/c8gc03876g

Authors: Zhichao Lu, Bhvandip S. Bajwa, Shiwen Liu, Sheye Lee, Gerald B. Hammond, Bo Xu

Institutions: University of Louisville, California State University System, California State University, Fresno, Donghua University

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: green

Funders: Camille and Henry Dreyfus Foundation, Lee Foundation, National Natural Science Foundation of China, National Institutes of Health, California State University, Fresno, National Institute of General Medical Sciences

Awards: G4645608422, Nucleophilic halogenation reagents

OpenAlex ID: W2913227679

FWCI: 0.853

Cites: 38

Cited by: 20

Related to: 10