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Cover Feature: Photoinducible Oncometabolite Detection (ChemBioChem 3/2019)

Year: 2019
Type: article
Abstract: The cover feature picture shows an optical illusion that can be viewed either as a white vase or the outline of two faces. By analogy, the nitrileimine–alkene cycloaddition, well known for its use in biorthogonal protein labeling, can also enable the fluorescent detection of endogenous molecules such as the oncometabolite fumarate, which accumulates in the hereditary cancer syndrome HLRCC. Applying this method to profile the activity of tricarboxylic acid cycle enzymes allowed the facile differentiation of healthy tissue and tumor in HLRCC patient samples, and enabled proof-of-concept experiments to establish the feasibility of oncometabolite imaging. More information can be found in the communication by J. L. Meier et al. on page 360 in Issue 3, 2019 (DOI: 10.1002/cbic.201800651).
Source: ChemBioChem
DOI: 10.1002/cbic.201900008
Authors: Rhushikesh A. Kulkarni, Chloe A. Briney, Daniel R. Crooks, Sarah E. Bergholtz, Chandrasekhar Mushti, Stephen J. Lockett, Andrew N. Lane, Teresa W.‐M. Fan, Rolf E. Swenson, W. Marston Linehan, Jordan L. Meier
Institutions: National Institutes of Health, National Cancer Institute, National Heart, Lung, and Blood Institute, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. (United States), University of Kentucky, Markey Cancer Center
Language: English
Field: Chemistry
Open Access status: bronze
OpenAlex ID: W2913297865
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