Parkinson’s Disease Biomarkers: Perspective from the NINDS Parkinson’s Disease Biomarkers Program
Year: 2017
Type: article
Abstract: Biomarkers for Parkinson's disease (PD) diagnosis, prognostication and clinical trial cohort selection are an urgent need. While many promising markers have been discovered through the National Institute of Neurological Disorders and Stroke Parkinson's Disease Biomarker Program (PDBP) and other mechanisms, no single PD marker or set of markers are ready for clinical use. Here we discuss the current state of biomarker discovery for platforms relevant to PDBP. We discuss the role of the PDBP in PD biomarker identification and present guidelines to facilitate their development. These guidelines include: harmonizing procedures for biofluid acquisition and clinical assessments, replication of the most promising biomarkers, support and encouragement of publications that report negative findings, longitudinal follow-up of current cohorts including the PDBP, testing of wearable technologies to capture readouts between study visits and development of recently diagnosed (de novo) cohorts to foster identification of the earliest markers of disease onset.
Source: Biomarkers in Medicine
Authors: Katrina Gwinn, Karen K David, Christine Swanson-Fischer, Roger Albin, Coryse St Hillaire-Clarke, Beth-Anne Sieber, Codrin Lungu, F DuBois Bowman, Roy N Alcalay, Debra Babcock, Ted M Dawson, Richard B Dewey, Tatiana Foroud, Dwight German, Xuemei Huang, Vlad Petyuk, Judith A Potashkin, Rachel Saunders-Pullman, Margaret Sutherland, David R Walt, Andrew B West, Jing Zhang, Alice Chen-Plotkin, Clemens R Scherzer, David E Vaillancourt, Liana S Rosenthal
Institutions: National Institutes of Health, National Institute of Neurological Disorders and Stroke, University of Michigan, VA Ann Arbor Healthcare System, National Institute on Aging, Columbia University, Johns Hopkins University, Johns Hopkins Medicine, The University of Texas Southwestern Medical Center, Indiana University Indianapolis, Indiana University School of Medicine, Pennsylvania State University, Penn State Milton S. Hershey Medical Center, Pacific Northwest National Laboratory, Rosalind Franklin University of Medicine and Science, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, Tufts University, University of Alabama at Birmingham, University of Washington, University of Pennsylvania, Brigham and Women's Hospital, Harvard University, University of Florida
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Innate and Adaptive Immunity in Parkinson Disease, Evaluation of glucocerebrosidase pathway biomarkers in Parkinson Disease, Penn State Clinical and Translational Science Institute, G2027453934, Pacific Udall Center, Efficacies and Pharmacodynamic Assays for LRRk2 Small-Molecule Inhibitors, The role of glucocerebrosidase in Parkinson's disease, Parkinson's Disease and Dementia, Johns Hopkins Medicine Biomarker Discovery in Parkinson's Disease, Blood RNA biomarkers of Parkinson's disease and progressive supranuclear palsy, Exosome LRRK2 in Predicting Parkinson Disease Phenotypes, Cholinergic mechanisms of attentional-motor integration and gait dysfunction in Parkinson Disease, A Next Generation of Biomarkers for Incipient Huntington Disease, Unbiased Approaches to Novel Biomarker Discovery in Parkinson's Disease, Biomarkers for early intervention in Parkinson disease, Multimodal MRI markers of nigrostriatal pathology in Parkinson's disease, Morris K. Udall Centers of Excellence for Parkinson's Disease Research (P50), GBA pathway markers for Lewy body dementias, Parkinson Disease: Predicting the Future, Serotonin and Amyloidopathy, Penn State Clinical and Translational Science Institute, Diagnostic and prognostic biomarkers for Parkinsons disease, G775008420, Towards a blood-based diagnostic panel for confirmation of Parkinson's disease, Development of Lewy Bodies Biofluid Signatures by Targeted Proteomics, Mechanisms of LRRK2 Mediated Neurotoxicity, Biospecimen Exchange for Neurological Disorders (BioSEND)
OpenAlex ID: W2692583471