Portable System for Time-Domain Diffuse Correlation Spectroscopy
Year: 2019
Type: article
Abstract: We introduce a portable system for clinical studies based on time-domain diffuse correlation spectroscopy (DCS). After evaluating different lasers and detectors, the final system is based on a pulsed laser with about 550 ps pulsewidth, a coherence length of 38 mm, and two types of single-photon avalanche diodes (SPAD). The higher efficiency of the red-enhanced SPAD maximizes detection of the collected light, increasing the signal-to-noise ratio, while the better timing response of the CMOS SPAD optimizes the selection of late photons and increases spatial resolution. We discuss component selection and performance, and we present a full characterization of the system, measurement stability, a phantom-based validation study, and preliminary in vivo results collected from the forearms and the foreheads of four healthy subjects. With this system, we are able to resolve blood flow changes 1 cm below the skin surface with improved depth sensitivity and spatial resolution with respect to continuous wave DCS.
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Time Domain-Diffuse Correlation Spectroscopy (TD-DCS), G2050378121, Non-invasive monitoring of brain health during cardio-pulmonary bypass, G5375263557, MICROSCOPIC FOUNDATION OF MULTIMODAL HUMAN IMAGING, G6988248355, Gated Diffuse Correlation Spectroscopy for functional imaging of the human brain, Center for Functional Imaging Technologies, NIRS-DCS for monitoring anesthesia and surgical manipulations of cerebral oxygen delivery
OpenAlex ID: W2913410661