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Donor Leukocyte Infusion Mediated Graft-Versus-Host Responses in a Pre-Clinical Swine Model of Haploidentical Hematopoietic Cell Transplantation

Year: 2016
Type: article
Abstract: The donor-anti-host cellular reactivity associated with allogeneic hematopoietic cell transplantation (HCT) is a powerful anti-leukemia treatment. However, graft-versus-host disease (GVHD) continues to limit HCT, especially across major histocompatibility (MHC) barriers. We previously described successful hematopoietic stem cell engraftment in MHC-mismatched swine without GVHD using novel reduced intensity conditioning (RIC) regimens consisting of partial, transient recipient T-cell depletion (with or without thymic or low-dose total body irradiation), and a short course of cyclosporine A (CyA).
DOI: 10.1016/j.bbmt.2015.11.788
Authors: Raimon Duran-Struuck, Abraham J. Matar, Rebecca L. Crepeau, Vimukthi Pathiraja, Thomas R. Spitzer, Roderick T. Bronson, David H. Sachs, Christene A. Huang
Institutions: University of Pennsylvania, University of Central Florida, Dartmouth College, Dartmouth Health, Harvard University, MGH Institute of Health Professions, Massachusetts General Hospital
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2913465081
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