APT‐weighted MRI: Techniques, current neuro applications, and challenging issues
Year: 2019
Type: review
Abstract: Amide proton transfer-weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we outline the technical challenges for clinical APT-based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo. Level of Evidence: 3 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019;50:347-364.
DOI: 10.1002/jmri.26645
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1231577361, G1445240721, Development of Novel Functional Markers for TBI Using Molecular MRI, Amide Proton Transfer (APT) MRI of Brain Tumors at 3T, Novel approaches for CEST labeling, detection, quantification and translation, G3007788965, G4221669636, Resource for Quantitative Functional FMRI, Amide Proton Transfer (APT) MRI of Brain Tumors at 3T, Highly Accelerated Chemical Exchange Saturation Transfer MRI Using Compressed Sensing, Academic-Industrial Partnership to Develop Clinical Brain Cancer Imaging
OpenAlex ID: W2913528204