Work

Human immunodeficiency virus and hepatotropic viruses co-morbidities as the inducers of liver injury progression

Year: 2019

Type: review

Abstract: Hepatotropic viruses induced hepatitis progresses much faster and causes more liver- related health problems in people co-infected with human immunodeficiency virus (HIV). Although treatment with antiretroviral therapy has extended the life expectancy of people with HIV, liver disease induced by hepatitis B virus (HBV) and hepatitis C virus (HCV) causes significant numbers of non-acquired immune deficiency syndrome (AIDS)-related deaths in co-infected patients. In recent years, new insights into the mechanisms of accelerated fibrosis and liver disease progression in HIV/HCV and HIV/HBV co-infections have been reported. In this paper, we review recent studies examining the natural history and pathogenesis of liver disease in HIV-HCV/HBV co-infection in the era of direct acting antivirals (DAA) and antiretroviral therapy (ART). We also review the novel therapeutics for management of HIV/HCV and HIV/HBV co-infected individuals.

Source: World Journal of Gastroenterology

DOI: 10.3748/wjg.v25.i4.398

Authors: Murali Ganesan, Larisa Y Poluektova, Kusum K Kharbanda, Natalia A Osna

Institutions: VA Nebraska Western Iowa Health Care System, University of Nebraska Medical Center

Language: English

Topic: Hepatitis C virus research

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism