Work

Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation

Year: 2019

Type: article

Abstract: cells in vivo. We found a population of conventional dendritic cells, but not border-associated macrophages or microglia, to be essential for licensing T cells to initiate neuroinflammation.

Source: Science Immunology

DOI: 10.1126/sciimmunol.aau8380

Authors: Sarah Mundt, Dunja Mrdjen, Sebastian G. Utz, Melanie Greter, Bettina Schreiner, Burkhard Becher

Institutions: University of Zurich, University Hospital Zurich

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Awards: The use of Mass-cytometry in multi-parameter immune cell analysis, The role of the NF?B-inducing kinase NIK in the development and function of cellular immunity, The role of the NF-kappa B inducing kinase NIK in central T cell tolerance and peripheral immune regulation

OpenAlex ID: W2913625932

FWCI: 15.32

Cites: 56

Cited by: 235

Related to: 10