Evaluating Pre-existing Cognitive Impairment and Anticholinergic Burden as Predictors of Post-operative Delirium following TAVI (Transcatheter Aortic Valve Implantation)
Year: 2017
Type: dissertation
Study design: Observational Study
Abstract: Post-operative delirium (POD) is common following Transcatheter Aortic Valve Implantation (TAVI) and is associated with adverse health outcomes. We hypothesized that cognitive impairment and anticholinergic burden may exacerbate risk of POD in TAVI due to their effects on cholinergic pathways underlying delirium. Cognitive deficits were screened using the Mini-Cog test before TAVI and anticholinergic burden assessed using the Anticholinergic Cognitive Burden (ACB) scale. Logistic regression adjusted for age, history of stroke, atrial fibrillation, diabetes and anesthesia found that neither the Mini-Cog (OR: 6.62, p=0.09) nor the ACB scale (OR: 1.62, p=0.17) were significant independent predictors of POD when assessed individually. When assessed together, patients screening positive on the Mini-Cog and with a high ACB scale score (OR 6.94, p=0.01) predicted increased risk of POD in a significant model (Ď 2 (6) =29.1, p
Source: TSpace (University of Toronto)
Author: Maisha M. Khan
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2913700170